Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-ß-induced Foxp3 expression.

Ikeda, Satoshi; Saijo, Shinobu; Murayama, Masanori A; Shimizu, Kenji; Akitsu, Aoi; Iwakura, Yoichiro

Ikeda, Satoshi; Saijo, Shinobu; Murayama, Masanori A; Shimizu, Kenji; Akitsu, Aoi; Iwakura, Yoichiro.

Affiliation

Ikeda S; Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan;

J Immunol ; 192(4): 1449-58, 2014 Feb 15.

Article in En | MEDLINE | ID: mdl-24431229

Subject(s)

Arthritis, Rheumatoid/immunology; Forkhead Transcription Factors/metabolism; Interleukin-1/metabolism; Interleukin-6/metabolism; Th17 Cells/metabolism; Adaptor Proteins, Signal Transducing/biosynthesis; Animals; Basic-Leucine Zipper Transcription Factors/biosynthesis; Cell Differentiation; Cells, Cultured; Forkhead Transcription Factors/biosynthesis; Interleukin 1 Receptor Antagonist Protein/deficiency; Interleukin 1 Receptor Antagonist Protein/genetics; Interleukin-17/metabolism; Interleukin-6/deficiency; Interleukin-6/genetics; Interleukins/biosynthesis; Interleukins/metabolism; Lymph Nodes/metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Nuclear Proteins/biosynthesis; Receptors, Interleukin-1 Type I/antagonists & inhibitors; Signal Transduction; Transforming Growth Factor beta/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Interleukin-6 / Interleukin-1 / Forkhead Transcription Factors / Th17 Cells Limits: Animals Language: En Journal: J Immunol Year: 2014 Type: Article

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