Cyclooxygenase-2 in endothelial and vascular smooth muscle cells restrains atherogenesis in hyperlipidemic mice.

Tang, Soon Yew; Monslow, James; Todd, Leslie; Lawson, John; Puré, Ellen; FitzGerald, Garret A

Tang, Soon Yew; Monslow, James; Todd, Leslie; Lawson, John; Puré, Ellen; FitzGerald, Garret A.

Affiliation

Tang SY; Institute for Translational Medicine and Therapeutics (S.Y.T., J.M., J.L., G.A.F.) and Perelman School of Medicine, Department of Animal Biology, School of Veterinary Medicine (L.T., E.P.), University of Pennsylvania, Philadelphia.

Circulation ; 129(17): 1761-9, 2014 Apr 29.

Article in En | MEDLINE | ID: mdl-24519928

Subject(s)

Atherosclerosis/metabolism; Cyclooxygenase 2/genetics; Endothelium, Vascular/enzymology; Hyperlipidemias/metabolism; Muscle, Smooth, Vascular/enzymology; Animals; Aorta, Thoracic/enzymology; Aorta, Thoracic/pathology; Atherosclerosis/epidemiology; Atherosclerosis/pathology; Blood Pressure/physiology; Cyclooxygenase 2/metabolism; Diet, Atherogenic; Dietary Fats/pharmacology; Dinoprostone/biosynthesis; Endothelium, Vascular/pathology; Epoprostenol/biosynthesis; Female; Hyperlipidemias/epidemiology; Hyperlipidemias/pathology; Macrophages/enzymology; Macrophages/pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular/pathology; Receptors, LDL/genetics; Risk Factors

Key words

atherogenesis; cyclooxygenase; endothelial cell; prostaglandin; vascular smooth muscle

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endothelium, Vascular / Atherosclerosis / Cyclooxygenase 2 / Hyperlipidemias / Muscle, Smooth, Vascular Type of study: Etiology_studies / Risk_factors_studies Limits: Animals Language: En Journal: Circulation Year: 2014 Type: Article

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