HCN2 channels account for mechanical (but not heat) hyperalgesia during long-standing inflammation.

Schnorr, Sabine; Eberhardt, Mirjam; Kistner, Katrin; Rajab, Hamsa; Käer, Johannes; Hess, Andreas; Reeh, Peter; Ludwig, Andreas; Herrmann, Stefan

Schnorr, Sabine; Eberhardt, Mirjam; Kistner, Katrin; Rajab, Hamsa; Käer, Johannes; Hess, Andreas; Reeh, Peter; Ludwig, Andreas; Herrmann, Stefan.

Affiliation

Schnorr S; Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany Institut für Physiologie und Pathophysiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany Klinik für Anästhesiologie und Intensivmedizin, Medizinische Hochschule Hannover, Hannover, Germany.

Pain ; 155(6): 1079-1090, 2014 Jun.

Article in En | MEDLINE | ID: mdl-24525276

Subject(s)

Hot Temperature/adverse effects; Hyperalgesia/genetics; Hyperalgesia/pathology; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels/physiology; Potassium Channels/physiology; Touch/genetics; Animals; Cells, Cultured; Inflammation/genetics; Inflammation/pathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Organ Culture Techniques; Physical Stimulation/adverse effects

Key words

DRG neurons; HCN channels; Hyperalgesia; Inflammatory pain; Primary sensory afferents

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Touch / Potassium Channels / Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels / Hot Temperature / Hyperalgesia Limits: Animals Language: En Journal: Pain Year: 2014 Type: Article Affiliation country: Germany

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