Delayed treatment with oleanolic acid attenuates tubulointerstitial fibrosis in chronic cyclosporine nephropathy through Nrf2/HO-1 signaling.

Hong, Yu Ah; Lim, Ji Hee; Kim, Min Young; Kim, Eun Nim; Koh, Eun Sil; Shin, Seok Joon; Choi, Bum Soon; Park, Cheol Whee; Chang, Yoon Sik; Chung, Sungjin

Hong, Yu Ah; Lim, Ji Hee; Kim, Min Young; Kim, Eun Nim; Koh, Eun Sil; Shin, Seok Joon; Choi, Bum Soon; Park, Cheol Whee; Chang, Yoon Sik; Chung, Sungjin.

Affiliation

Chung S; Department of Internal Medicine, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seoul 137-701, Republic of Korea. sungjin.chung@outlook.com.

J Transl Med ; 12: 50, 2014 Feb 21.

Article in En | MEDLINE | ID: mdl-24559268

Subject(s)

Cyclosporine/adverse effects; Heme Oxygenase-1/metabolism; Kidney Diseases/chemically induced; Kidney Diseases/drug therapy; Kidney Tubules/pathology; NF-E2-Related Factor 2/metabolism; Oleanolic Acid/therapeutic use; Adaptor Proteins, Signal Transducing/metabolism; Animals; Antioxidants/metabolism; Apoptosis/drug effects; Biomarkers/metabolism; Cell Nucleus/drug effects; Cell Nucleus/metabolism; Cytoskeletal Proteins/metabolism; Fibrosis; Kelch-Like ECH-Associated Protein 1; Kidney Diseases/enzymology; Kidney Diseases/physiopathology; Kidney Function Tests; Kidney Tubules/drug effects; Male; Malondialdehyde/metabolism; Mice; Mice, Inbred ICR; NAD(P)H Dehydrogenase (Quinone)/metabolism; Oleanolic Acid/pharmacology; Proto-Oncogene Proteins c-bcl-2/metabolism; Signal Transduction/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oleanolic Acid / Cyclosporine / Heme Oxygenase-1 / NF-E2-Related Factor 2 / Kidney Diseases / Kidney Tubules Limits: Animals Language: En Journal: J Transl Med Year: 2014 Type: Article

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