Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans.

Cai, Weijing; Uribarri, Jaime; Zhu, Li; Chen, Xue; Swamy, Shobha; Zhao, Zhengshan; Grosjean, Fabrizio; Simonaro, Calogera; Kuchel, George A; Schnaider-Beeri, Michal; Woodward, Mark; Striker, Gary E; Vlassara, Helen

Cai, Weijing; Uribarri, Jaime; Zhu, Li; Chen, Xue; Swamy, Shobha; Zhao, Zhengshan; Grosjean, Fabrizio; Simonaro, Calogera; Kuchel, George A; Schnaider-Beeri, Michal; Woodward, Mark; Striker, Gary E; Vlassara, Helen.

Affiliation

Cai W; Department of Geriatrics, Division of Experimental Diabetes, Medicine, Human Genetics, and Psychiatry, The Icahn School of Medicine at Mount Sinai, New York, NY 10029.

Proc Natl Acad Sci U S A ; 111(13): 4940-5, 2014 Apr 01.

Article in En | MEDLINE | ID: mdl-24567379

Subject(s)

Dementia/pathology; Glycation End Products, Advanced/adverse effects; Metabolic Syndrome/pathology; Pyruvaldehyde/adverse effects; ADAM Proteins/genetics; ADAM Proteins/metabolism; ADAM10 Protein; Administration, Oral; Aged; Amyloid Precursor Protein Secretases/genetics; Amyloid Precursor Protein Secretases/metabolism; Amyloid beta-Peptides/metabolism; Animals; Brain/drug effects; Brain/pathology; Brain/physiopathology; Cognition/drug effects; Cytokines/metabolism; Dementia/blood; Dementia/physiopathology; Female; Gliosis/metabolism; Gliosis/pathology; Gliosis/physiopathology; Glycation End Products, Advanced/administration & dosage; Glycation End Products, Advanced/toxicity; Humans; Insulin/pharmacology; Male; Membrane Proteins/genetics; Membrane Proteins/metabolism; Memory/drug effects; Metabolic Syndrome/blood; Metabolic Syndrome/physiopathology; Mice; Mice, Inbred C57BL; Middle Aged; Nicotinamide Phosphoribosyltransferase/metabolism; Oxidative Stress/drug effects; PPAR gamma/metabolism; Pyruvaldehyde/administration & dosage; Pyruvaldehyde/blood; Pyruvaldehyde/toxicity; Receptor for Advanced Glycation End Products; Receptors, Immunologic/metabolism; Sirtuin 1/antagonists & inhibitors; Sirtuin 1/metabolism; Time Factors; Transcription, Genetic/drug effects

Key words

caloric restriction; insulin resistance; neural; nutrition; obesity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyruvaldehyde / Glycation End Products, Advanced / Metabolic Syndrome / Dementia Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: Proc Natl Acad Sci U S A Year: 2014 Type: Article

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