Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket.

Saalau-Bethell, Susanne M; Berdini, Valerio; Cleasby, Anne; Congreve, Miles; Coyle, Joseph E; Lock, Victoria; Murray, Christopher W; O'Brien, M Alistair; Rich, Sharna J; Sambrook, Tracey; Vinkovic, Mladen; Yon, Jeff R; Jhoti, Harren

Saalau-Bethell, Susanne M; Berdini, Valerio; Cleasby, Anne; Congreve, Miles; Coyle, Joseph E; Lock, Victoria; Murray, Christopher W; O'Brien, M Alistair; Rich, Sharna J; Sambrook, Tracey; Vinkovic, Mladen; Yon, Jeff R; Jhoti, Harren.

Affiliation

Saalau-Bethell SM; Astex Pharmaceuticals, Cambridge Science Park, Cambridge, CB4 0QA (UK).

ChemMedChem ; 9(4): 823-32, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24616449

Subject(s)

Adenylyl Cyclase Inhibitors; Bicarbonates/pharmacology; Enzyme Inhibitors/pharmacology; Adenylyl Cyclases/chemistry; Adenylyl Cyclases/metabolism; Bicarbonates/chemical synthesis; Bicarbonates/chemistry; Catalytic Domain/drug effects; Crystallography, X-Ray; Dose-Response Relationship, Drug; Enzyme Activation/drug effects; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/chemistry; Humans; Models, Molecular; Structure-Activity Relationship

Key words

allosterism; drug discovery; enzyme regulation; fragment screening; structural biology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bicarbonates / Enzyme Inhibitors / Adenylyl Cyclase Inhibitors Limits: Humans Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2014 Type: Article

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