Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function.

Ghonime, Mohammed G; Shamaa, Obada R; Das, Srabani; Eldomany, Ramadan A; Fernandes-Alnemri, Teresa; Alnemri, Emad S; Gavrilin, Mikhail A; Wewers, Mark D

Ghonime, Mohammed G; Shamaa, Obada R; Das, Srabani; Eldomany, Ramadan A; Fernandes-Alnemri, Teresa; Alnemri, Emad S; Gavrilin, Mikhail A; Wewers, Mark D.

Affiliation

Ghonime MG; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210;

J Immunol ; 192(8): 3881-8, 2014 Apr 15.

Article in En | MEDLINE | ID: mdl-24623131

Subject(s)

Inflammasomes; Lipopolysaccharides/immunology; MAP Kinase Signaling System; Proteasome Endopeptidase Complex/metabolism; Carrier Proteins/metabolism; Caspase 1/metabolism; Gene Expression Regulation/drug effects; Humans; Immunity, Innate; Inflammation/genetics; Inflammation/immunology; Inflammation/metabolism; Interleukin-18/metabolism; Interleukin-1beta/metabolism; MAP Kinase Signaling System/drug effects; Mitogen-Activated Protein Kinase 1/genetics; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/genetics; Mitogen-Activated Protein Kinase 3/metabolism; Models, Biological; Monocytes/immunology; Monocytes/metabolism; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidants/pharmacology; Protein Kinase Inhibitors/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lipopolysaccharides / MAP Kinase Signaling System / Proteasome Endopeptidase Complex / Inflammasomes Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Immunol Year: 2014 Type: Article

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