ATF7IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children.
Br J Haematol
; 165(6): 836-41, 2014 Jun.
Article
in En
| MEDLINE
| ID: mdl-24628626
ABSTRACT
We identified ATF7IP as a novel PDGFRB fusion partner in B-progenitor acute lymphoblastic leukaemia (B-ALL) and showed that B-ALL with ATF7IP/PDGFRB translocation is included within the genomic lesions of a Philadelphia chromosome (Ph)-like ALL subgroup. Comprehensive analyses of previous repositories of gene expression data sets disclosed that B-ALL cases with high PDGFRB expression level in the context of the Ph-like ALL gene are likely to have a PDGFRB translocation. Thus, it is possible that measurement of the PDGFRB expression level can be utilized as a screening test for the detection of the cryptic PDGFRB translocation, especially within the Ph-like ALL subgroup.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transcription Factors
/
Oncogene Proteins, Fusion
/
Receptor, Platelet-Derived Growth Factor beta
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Child
/
Humans
/
Male
Language:
En
Journal:
Br J Haematol
Year:
2014
Type:
Article
Affiliation country:
Japan