Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6.

Stamos, Jennifer L; Chu, Matthew Ling-Hon; Enos, Michael D; Shah, Niket; Weis, William I

Stamos, Jennifer L; Chu, Matthew Ling-Hon; Enos, Michael D; Shah, Niket; Weis, William I.

Affiliation

Stamos JL; Department of Structural Biology, Stanford University, Stanford, United States.

Elife ; 3: e01998, 2014 Mar 18.

Article in En | MEDLINE | ID: mdl-24642411

Subject(s)

Glycogen Synthase Kinase 3/antagonists & inhibitors; Amino Acid Sequence; Animals; Catalysis; Crystallography, X-Ray; Glycogen Synthase Kinase 3/chemistry; Glycogen Synthase Kinase 3/metabolism; Humans; Molecular Sequence Data; Phosphorylation; Protein Conformation; Sequence Homology, Amino Acid; Substrate Specificity

Key words

GSK-3; LRP6; Wnt signaling; protein kinase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glycogen Synthase Kinase 3 Limits: Animals / Humans Language: En Journal: Elife Year: 2014 Type: Article Affiliation country: United States

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