GABAergic signaling facilitates breast cancer metastasis by promoting ERK1/2-dependent phosphorylation.

Zhang, Depu; Li, Xiaowei; Yao, Ziming; Wei, Chuanfei; Ning, Nannan; Li, Jingxin

Zhang, Depu; Li, Xiaowei; Yao, Ziming; Wei, Chuanfei; Ning, Nannan; Li, Jingxin.

Affiliation

Zhang D; Department of Physiology, School of Medicine, Shandong University, Jinan 250012, China.
Li X; Department of Physiology, School of Medicine, Shandong University, Jinan 250012, China.
Yao Z; Department of Physiology, School of Medicine, Shandong University, Jinan 250012, China.
Wei C; Department of Physiology, School of Medicine, Shandong University, Jinan 250012, China.
Ning N; Department of Physiology, School of Medicine, Shandong University, Jinan 250012, China.
Li J; Department of Physiology, School of Medicine, Shandong University, Jinan 250012, China. Electronic address: ljingxin@sdu.edu.cn.

Cancer Lett ; 348(1-2): 100-8, 2014 Jun 28.

Article in En | MEDLINE | ID: mdl-24657659

Subject(s)

Breast Neoplasms/enzymology; Breast Neoplasms/pathology; Cell Movement; Lung Neoplasms/enzymology; Lung Neoplasms/secondary; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Signal Transduction; gamma-Aminobutyric Acid/metabolism; Animals; Cell Movement/drug effects; Dose-Response Relationship, Drug; Female; GABA-B Receptor Agonists/pharmacology; GABA-B Receptor Antagonists/pharmacology; Glutamate Decarboxylase/metabolism; Humans; MCF-7 Cells; Matrix Metalloproteinase 2/metabolism; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Phosphorylation; Receptors, GABA-B/drug effects; Receptors, GABA-B/metabolism; Signal Transduction/drug effects; Time Factors

Key words

Breast cancer; ERK; GABA receptor; Metastasis; Î³-Aminobutyric acid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Signal Transduction / Cell Movement / Mitogen-Activated Protein Kinase 1 / Mitogen-Activated Protein Kinase 3 / Gamma-Aminobutyric Acid / Lung Neoplasms Limits: Animals / Female / Humans Language: En Journal: Cancer Lett Year: 2014 Type: Article Affiliation country: China

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