Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening.

Garimella, Sireesha V; Gehlhaus, Kristie; Dine, Jennifer L; Pitt, Jason J; Grandin, Magdalena; Chakka, Sirisha; Nau, Marion M; Caplen, Natasha J; Lipkowitz, Stanley

Garimella, Sireesha V; Gehlhaus, Kristie; Dine, Jennifer L; Pitt, Jason J; Grandin, Magdalena; Chakka, Sirisha; Nau, Marion M; Caplen, Natasha J; Lipkowitz, Stanley.

Breast Cancer Res ; 16(2): R41, 2014 Apr 17.

Article in En | MEDLINE | ID: mdl-24745479

Subject(s)

Apoptosis/drug effects; Apoptosis/genetics; Gene Expression Regulation, Neoplastic/drug effects; RNA Interference; TNF-Related Apoptosis-Inducing Ligand/pharmacology; Biphenyl Compounds/pharmacology; Breast Neoplasms/genetics; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Caspase 3/genetics; Caspase 3/metabolism; Caspase 7/genetics; Caspase 7/metabolism; Caspase 8/genetics; Caspase 8/metabolism; Cell Line, Tumor; Cell Survival/drug effects; Cell Survival/genetics; Cysteine Proteinase Inhibitors/pharmacology; Drug Resistance, Neoplasm/genetics; Humans; Immunoblotting; Nitrophenols/pharmacology; Oligopeptides/pharmacology; Piperazines/pharmacology; Pyrimidines/pharmacology; Sulfonamides/pharmacology; bcl-X Protein/antagonists & inhibitors; bcl-X Protein/genetics; bcl-X Protein/metabolism; src-Family Kinases/antagonists & inhibitors; src-Family Kinases/genetics; src-Family Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation, Neoplastic / Apoptosis / RNA Interference / TNF-Related Apoptosis-Inducing Ligand Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Humans Language: En Journal: Breast Cancer Res Journal subject: NEOPLASIAS Year: 2014 Type: Article

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