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Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis.
Grube, Susanne; Dünisch, Pedro; Freitag, Diana; Klausnitzer, Maren; Sakr, Yasser; Walter, Jan; Kalff, Rolf; Ewald, Christian.
Affiliation
  • Grube S; Department of Neurosurgery, Section of Experimental Neurooncology, Jena University Hospital, Friedrich-Schiller-University Jena, Erlanger Allee 101, 07747, Jena, Germany. susanne.grube@med.uni-jena.de.
  • Dünisch P; Department of Neurosurgery, Section of Experimental Neurooncology, Jena University Hospital, Friedrich-Schiller-University Jena, Erlanger Allee 101, 07747, Jena, Germany.
  • Freitag D; Department of Neurosurgery, Section of Experimental Neurooncology, Jena University Hospital, Friedrich-Schiller-University Jena, Erlanger Allee 101, 07747, Jena, Germany.
  • Klausnitzer M; Department of Neurosurgery, Section of Experimental Neurooncology, Jena University Hospital, Friedrich-Schiller-University Jena, Erlanger Allee 101, 07747, Jena, Germany.
  • Sakr Y; Department of Anesthesiology and Intensive Care, Jena University Hospital, Friedrich-Schiller-University Jena, Erlanger Allee 101, 07747, Jena, Germany.
  • Walter J; Department of Neurosurgery, Section of Experimental Neurooncology, Jena University Hospital, Friedrich-Schiller-University Jena, Erlanger Allee 101, 07747, Jena, Germany.
  • Kalff R; Department of Neurosurgery, Section of Experimental Neurooncology, Jena University Hospital, Friedrich-Schiller-University Jena, Erlanger Allee 101, 07747, Jena, Germany.
  • Ewald C; Department of Neurosurgery, Section of Experimental Neurooncology, Jena University Hospital, Friedrich-Schiller-University Jena, Erlanger Allee 101, 07747, Jena, Germany.
J Neurooncol ; 118(2): 277-287, 2014 Jun.
Article in En | MEDLINE | ID: mdl-24789255
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Apoptosis / Fatty Acid Synthase, Type I / Fatty Acid Synthesis Inhibitors / Glioma / Lactones Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Neurooncol Year: 2014 Type: Article Affiliation country: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Apoptosis / Fatty Acid Synthase, Type I / Fatty Acid Synthesis Inhibitors / Glioma / Lactones Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Neurooncol Year: 2014 Type: Article Affiliation country: Germany