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Eunicellin-based diterpenoids, hirsutalins N-R, from the formosan soft coral Cladiella hirsuta.
Huang, Tzu-Zin; Chen, Bo-Wei; Huang, Chiung-Yao; Hwang, Tsong-Long; Dai, Chang-Feng; Sheu, Jyh-Horng.
Affiliation
  • Huang TZ; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. slime112229@gmail.com.
  • Chen BW; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. a6152761@yahoo.com.tw.
  • Huang CY; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. betty8575@yahoo.com.tw.
  • Hwang TL; Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
  • Dai CF; Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan. corallab@ntu.edu.tw.
  • Sheu JH; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. sheu@mail.nsysu.edu.tw.
Mar Drugs ; 12(5): 2446-57, 2014 Apr 30.
Article in En | MEDLINE | ID: mdl-24796303
ABSTRACT
New eunicellin-type hirsutalins N-R (1-5), along with two known eunicellins, (6 and 7) were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxic activity of compounds 1-7 against the proliferation of a limited panel of cancer cell lines was measured. The in vitro anti-inflammatory activity of compounds 1-7 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anthozoa / Diterpenes Limits: Animals / Humans Country/Region as subject: Asia Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2014 Type: Article Affiliation country: Taiwan
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anthozoa / Diterpenes Limits: Animals / Humans Country/Region as subject: Asia Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2014 Type: Article Affiliation country: Taiwan