miR-21 regulates N-methyl-N-nitro-N'-nitrosoguanidine-induced gastric tumorigenesis by targeting FASLG and BTG2.

Yang, Qiaoyuan; Xu, Enwu; Dai, Jiabin; Wu, Jianjun; Zhang, Shaozhu; Peng, Baoying; Jiang, Yiguo

Yang, Qiaoyuan; Xu, Enwu; Dai, Jiabin; Wu, Jianjun; Zhang, Shaozhu; Peng, Baoying; Jiang, Yiguo.

Affiliation

Yang Q; Institute for Chemical Carcinogenesis, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou 510182, PR China.
Xu E; Department of Thoracic Surgery, General Hospital of Guangzhou Military Command of Chinese People's Liberation Army, Guangzhou 510010, PR China.
Dai J; Institute for Chemical Carcinogenesis, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou 510182, PR China.
Wu J; Institute for Chemical Carcinogenesis, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou 510182, PR China.
Zhang S; Institute for Chemical Carcinogenesis, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou 510182, PR China.
Peng B; Institute for Chemical Carcinogenesis, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou 510182, PR China.
Jiang Y; Institute for Chemical Carcinogenesis, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou 510182, PR China. Electronic address: jiangyiguo@vip.163.com.

Toxicol Lett ; 228(3): 147-56, 2014 Aug 04.

Article in En | MEDLINE | ID: mdl-24821435

Subject(s)

Carcinogens/toxicity; Cell Transformation, Neoplastic/chemically induced; Fas Ligand Protein/metabolism; Immediate-Early Proteins/metabolism; Methylnitronitrosoguanidine/toxicity; MicroRNAs/metabolism; Stomach Neoplasms/chemically induced; Tumor Suppressor Proteins/metabolism; 3' Untranslated Regions; Animals; Apoptosis; Binding Sites; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic/genetics; Cell Transformation, Neoplastic/metabolism; Cell Transformation, Neoplastic/pathology; Dose-Response Relationship, Drug; Fas Ligand Protein/genetics; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Immediate-Early Proteins/genetics; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs/genetics; RNA Interference; Stomach Neoplasms/genetics; Stomach Neoplasms/metabolism; Stomach Neoplasms/pathology; Time Factors; Transfection; Tumor Suppressor Proteins/genetics

Key words

Gastric cancer; MNNG; MicroRNA; Tumorigenesis; miR-21

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Carcinogens / Cell Transformation, Neoplastic / Immediate-Early Proteins / Tumor Suppressor Proteins / MicroRNAs / Fas Ligand Protein / Methylnitronitrosoguanidine Limits: Animals / Humans Language: En Journal: Toxicol Lett Year: 2014 Type: Article

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