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Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP.
Johnson, Michael G; Liu, Jim Jiwen; Li, An-Rong; van Lengerich, Bettina; Wang, Sophie; Medina, Julio C; Collins, Tassie L; Danao, Jay; Seitz, Lisa; Willee, Angela; D'Souza, Warren; Budelsky, Alison L; Fan, Peter W; Wong, Simon G W.
Affiliation
  • Johnson MG; Department of Therapeutic Discovery, Amgen, Inc., 1120 Veterans Blvd, South San Francisco, CA 94080, USA. Electronic address: mgjohnso@amgen.com.
  • Liu JJ; Department of Therapeutic Discovery, Amgen, Inc., 1120 Veterans Blvd, South San Francisco, CA 94080, USA.
  • Li AR; Department of Therapeutic Discovery, Amgen, Inc., 1120 Veterans Blvd, South San Francisco, CA 94080, USA.
  • van Lengerich B; Department of Therapeutic Discovery, Amgen, Inc., 1120 Veterans Blvd, South San Francisco, CA 94080, USA.
  • Wang S; Department of Therapeutic Discovery, Amgen, Inc., 1120 Veterans Blvd, South San Francisco, CA 94080, USA.
  • Medina JC; Department of Therapeutic Discovery, Amgen, Inc., 1120 Veterans Blvd, South San Francisco, CA 94080, USA.
  • Collins TL; Department of Inflammation Research, Amgen, Inc., 1201 Amgen Court West, Seattle, WA 98119, USA.
  • Danao J; Department of Inflammation Research, Amgen, Inc., 1201 Amgen Court West, Seattle, WA 98119, USA.
  • Seitz L; Department of Inflammation Research, Amgen, Inc., 1201 Amgen Court West, Seattle, WA 98119, USA.
  • Willee A; Department of Inflammation Research, Amgen, Inc., 1201 Amgen Court West, Seattle, WA 98119, USA.
  • D'Souza W; Department of Inflammation Research, Amgen, Inc., 1201 Amgen Court West, Seattle, WA 98119, USA.
  • Budelsky AL; Department of Inflammation Research, Amgen, Inc., 1201 Amgen Court West, Seattle, WA 98119, USA.
  • Fan PW; Department of Pharmacokinetics, Metabolism and Distribution, Amgen, Inc., 1120 Veterans Blvd, South San Francisco, CA 94080, USA.
  • Wong SG; Department of Pharmacokinetics, Metabolism and Distribution, Amgen, Inc., 1120 Veterans Blvd, South San Francisco, CA 94080, USA.
Bioorg Med Chem Lett ; 24(13): 2877-80, 2014 Jul 01.
Article in En | MEDLINE | ID: mdl-24825301
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylacetates / Receptors, Prostaglandin / Receptors, Immunologic / Enzyme Inhibitors / Cytochrome P-450 CYP3A / Indoles Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylacetates / Receptors, Prostaglandin / Receptors, Immunologic / Enzyme Inhibitors / Cytochrome P-450 CYP3A / Indoles Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Type: Article