Influence of genetic polymorphisms of FPGS, GGH, and MTHFR on serum methotrexate levels in Chinese children with acute lymphoblastic leukemia.

Wang, Shu-mei; Sun, Lu-lu; Zeng, Wei-xin; Wu, Wan-shui; Zhang, Guo-liang

Wang, Shu-mei; Sun, Lu-lu; Zeng, Wei-xin; Wu, Wan-shui; Zhang, Guo-liang.

Affiliation

Wang SM; Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

Cancer Chemother Pharmacol ; 74(2): 283-9, 2014 Aug.

Article in En | MEDLINE | ID: mdl-24908438

Subject(s)

Methotrexate/blood; Methylenetetrahydrofolate Reductase (NADPH2)/genetics; Peptide Synthases/genetics; Polymorphism, Single Nucleotide/genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics; gamma-Glutamyl Hydrolase/genetics; Adolescent; Asian People/genetics; Child; Child, Preschool; DNA/analysis; DNA/genetics; Female; Follow-Up Studies; Humans; Immunoenzyme Techniques; Infant; Male; Methotrexate/administration & dosage; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy; Prognosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Synthases / Gamma-Glutamyl Hydrolase / Methotrexate / Polymorphism, Single Nucleotide / Methylenetetrahydrofolate Reductase (NADPH2) / Precursor Cell Lymphoblastic Leukemia-Lymphoma Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Cancer Chemother Pharmacol Year: 2014 Type: Article Affiliation country: China

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