Additives to preservation solutions.
Prog Urol
; 24 Suppl 1: S31-6, 2014 Jun.
Article
in En
| MEDLINE
| ID: mdl-24950930
ABSTRACT
As the impact of ischemia reperfusion injury on graft outcome is now well defined, efforts are made towards decreasing these lesions, typically through the improvement of preservation techniques. The use of pharmacological supplements which could be compatible with any preservation solution used by the transplant center and target specific pathways of IR is an interesting strategy to improve graft quality. However, the extensive number of studies showing the benefits a molecule in an animal model of IR without thorough mechanistic determination of the effects of this agent make it difficult to opt for specific pharmaceutical intervention. Herein we expose studies which demonstrate the benefits of several molecules relying on a thorough mechanical analysis of the events occurring during preservation, both at the cellular and the systemic levels. We believe this approach is the most appropriate to truly understand the potential benefits of a molecule and particularly to design a comprehensive pharmaceutical regiment, with several agents acting synergistically against IR, to improve organ preservation and graft outcome.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Reperfusion Injury
/
Kidney Transplantation
/
Organ Preservation Solutions
/
Kidney
Type of study:
Etiology_studies
Limits:
Humans
Language:
En
Journal:
Prog Urol
Journal subject:
UROLOGIA
Year:
2014
Type:
Article
Affiliation country:
France