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Tryptophanol-derived oxazolopiperidone lactams: identification of a hit compound as NMDA receptor antagonist.
Pereira, Nuno A L; Sureda, Francesc X; Esplugas, Roser; Pérez, Maria; Amat, Mercedes; Santos, Maria M M.
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  • Pereira NA; Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.
  • Sureda FX; Pharmacology Unit, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, c./St. Llorenç 21, 43201 Reus (Tarragona), Spain.
  • Esplugas R; Pharmacology Unit, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, c./St. Llorenç 21, 43201 Reus (Tarragona), Spain.
  • Pérez M; Laboratory of Organic Chemistry, Faculty of Pharmacy and Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII, s/n, 08028 Barcelona, Spain.
  • Amat M; Laboratory of Organic Chemistry, Faculty of Pharmacy and Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII, s/n, 08028 Barcelona, Spain.
  • Santos MM; Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal. Electronic address: mariasantos@ff.ul.pt.
Bioorg Med Chem Lett ; 24(15): 3333-6, 2014 Aug 01.
Article in En | MEDLINE | ID: mdl-24974339
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidones / Tryptophan / Receptors, N-Methyl-D-Aspartate / Indoles / Lactams Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Type: Article Affiliation country: Portugal
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidones / Tryptophan / Receptors, N-Methyl-D-Aspartate / Indoles / Lactams Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Type: Article Affiliation country: Portugal