Neurotropic astrovirus in cattle with nonsuppurative encephalitis in Europe.
J Clin Microbiol
; 52(9): 3318-24, 2014 Sep.
Article
in En
| MEDLINE
| ID: mdl-24989603
ABSTRACT
Encephalitis is a frequently diagnosed condition in cattle with neurological diseases. Many affected animals present with a nonsuppurative inflammatory reaction pattern in the brain. While this pattern supports a viral etiology, the causative pathogen remains unknown in a large proportion of cases. Using viral metagenomics, we identified an astrovirus (bovine astrovirus [BoAstV]-CH13) in the brain of a cow with nonsuppurative encephalitis. Additionally, BoAstV RNA was detected with reverse transcription-PCR and in situ hybridization in about one fourth (5/22 animals) of cattle with nonsuppurative encephalitis of unknown etiology. Viral RNA was found primarily in neurons and at the site of pathology. These findings support the notion that BoAstV infection is a common cause of encephalitis in cattle. Phylogenetically, BoAstV-CH13 was closely related to rare astrovirus isolates from encephalitis cases in animals and a human patient. Future research needs to be directed toward the pathogenic mechanisms, epidemiology, and potential cross-species transmission of these neurotropic astroviruses.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mamastrovirus
/
Cattle Diseases
/
Encephalitis, Viral
/
Astroviridae Infections
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
Country/Region as subject:
Europa
Language:
En
Journal:
J Clin Microbiol
Year:
2014
Type:
Article
Affiliation country:
Switzerland