Dasatinib induces fast and deep responses in newly diagnosed chronic myeloid leukaemia patients in chronic phase: clinical results from a randomised phase-2 study (NordCML006).

Hjorth-Hansen, Henrik; Stenke, Leif; Söderlund, Stina; Dreimane, Arta; Ehrencrona, Hans; Gedde-Dahl, Tobias; Gjertsen, Bjørn Tore; Höglund, Martin; Koskenvesa, Perttu; Lotfi, Kourosh; Majeed, Waleed; Markevärn, Berit; Ohm, Lotta; Olsson-Strömberg, Ulla; Remes, Kari; Suominen, Merja; Simonsson, Bengt; Porkka, Kimmo; Mustjoki, Satu; Richter, Johan

Hjorth-Hansen, Henrik; Stenke, Leif; Söderlund, Stina; Dreimane, Arta; Ehrencrona, Hans; Gedde-Dahl, Tobias; Gjertsen, Bjørn Tore; Höglund, Martin; Koskenvesa, Perttu; Lotfi, Kourosh; Majeed, Waleed; Markevärn, Berit; Ohm, Lotta; Olsson-Strömberg, Ulla; Remes, Kari; Suominen, Merja; Simonsson, Bengt; Porkka, Kimmo; Mustjoki, Satu; Richter, Johan.

Affiliation

Hjorth-Hansen H; Department of Hematology, St Olavs Hospital, Trondheim, Norway; Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Eur J Haematol ; 94(3): 243-50, 2015 Mar.

Article in En | MEDLINE | ID: mdl-25082346

Subject(s)

Antineoplastic Agents/therapeutic use; Benzamides/therapeutic use; Fusion Proteins, bcr-abl/antagonists & inhibitors; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy; Piperazines/therapeutic use; Protein Kinase Inhibitors/therapeutic use; Pyrimidines/therapeutic use; Thiazoles/therapeutic use; Adult; Aged; Dasatinib; Drug Administration Schedule; Female; Follow-Up Studies; Fusion Proteins, bcr-abl/genetics; Fusion Proteins, bcr-abl/metabolism; Gene Expression; Humans; Hydroxyurea/therapeutic use; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/mortality; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology; Male; Middle Aged; Remission Induction; Risk; Survival Analysis

Key words

dasatinib; deep response; imatinib; randomized controlled trial; toxicity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Pyrimidines / Thiazoles / Benzamides / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Fusion Proteins, bcr-abl / Protein Kinase Inhibitors / Antineoplastic Agents Type of study: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Eur J Haematol Journal subject: HEMATOLOGIA Year: 2015 Type: Article Affiliation country: Norway

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