Use of whole genome expression analysis in the toxicity screening of nanoparticles.

Fröhlich, Eleonore; Meindl, Claudia; Wagner, Karin; Leitinger, Gerd; Roblegg, Eva

Fröhlich, Eleonore; Meindl, Claudia; Wagner, Karin; Leitinger, Gerd; Roblegg, Eva.

Affiliation

Fröhlich E; Center for Medical Research, Medical University of Graz, Stiftingtalstr. 24, 8010 Graz, Austria. Electronic address: eleonore.froehlich@medunigraz.at.
Meindl C; Center for Medical Research, Medical University of Graz, Stiftingtalstr. 24, 8010 Graz, Austria.
Wagner K; Center for Medical Research, Medical University of Graz, Stiftingtalstr. 24, 8010 Graz, Austria.
Leitinger G; Center for Medical Research, Medical University of Graz, Stiftingtalstr. 24, 8010 Graz, Austria; Institute for Cell Biology, Histology and Embryology, Medical University of Graz, Harrachgasse 21, 8010 Graz, Austria.
Roblegg E; Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology, Karl-Franzens-University of Graz, Universitätsplatz 1, 8010 Graz, Austria.

Toxicol Appl Pharmacol ; 280(2): 272-84, 2014 Oct 15.

Article in En | MEDLINE | ID: mdl-25102311

Subject(s)

Gene Expression Regulation/drug effects; Nanoparticles/toxicity; Apoptosis/drug effects; Cell Survival/drug effects; Cells, Cultured; Endothelial Cells/drug effects; Endothelial Cells/metabolism; Humans; Interleukin-6/metabolism; Interleukin-8/metabolism; Nanotubes, Carbon; Oligonucleotide Array Sequence Analysis; Oxidative Stress/drug effects; Particle Size; Polystyrenes/toxicity

Key words

Apoptosis; Cytotoxicity; Interleukin secretion; Nanotoxicology; Oxidative stress; Whole genome expression analysis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / Nanoparticles Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Humans Language: En Journal: Toxicol Appl Pharmacol Year: 2014 Type: Article

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