A commonly used Drosophila model of Alzheimer's disease generates an aberrant species of amyloid-ß with an additional N-terminal glutamine residue.

Allan, Kirsten; Perez, Keyla A; Barnham, Kevin J; Camakaris, James; Burke, Richard

Allan, Kirsten; Perez, Keyla A; Barnham, Kevin J; Camakaris, James; Burke, Richard.

Affiliation

Allan K; Department of Genetics, University of Melbourne, Australia.
Perez KA; Florey Department of Neuroscience and Mental Health, The University of Melbourne, Australia.
Barnham KJ; Bio21 Institute, The University of Melbourne, Australia.
Camakaris J; Florey Department of Neuroscience and Mental Health, The University of Melbourne, Australia.
Burke R; School of Biological Sciences, Monash University, Australia. Electronic address: richard.burke@monash.edu.

FEBS Lett ; 588(20): 3739-43, 2014 Oct 16.

Article in En | MEDLINE | ID: mdl-25171862

Subject(s)

Alzheimer Disease/metabolism; Amyloid beta-Peptides/chemistry; Drosophila/metabolism; Peptide Fragments/chemistry; Phenotype; Alzheimer Disease/genetics; Amino Acid Sequence; Amyloid beta-Peptides/genetics; Amyloid beta-Peptides/metabolism; Animals; Drosophila/genetics; Drosophila/physiology; Glutamine/chemistry; Molecular Sequence Data; Peptide Fragments/genetics; Peptide Fragments/metabolism; Protein Sorting Signals; Protein Structure, Tertiary

Key words

Alzheimer's disease; Amyloid; Drosophila; Neurodegeneration; Signal peptide

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Phenotype / Amyloid beta-Peptides / Drosophila / Alzheimer Disease Limits: Animals Language: En Journal: FEBS Lett Year: 2014 Type: Article Affiliation country: Australia

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