Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis.

Selenica, Maj-Linda B; Davtyan, Hayk; Housley, Steven B; Blair, Laura J; Gillies, Anne; Nordhues, Bryce A; Zhang, Bo; Liu, Joseph; Gestwicki, Jason E; Lee, Daniel C; Gordon, Marcia N; Morgan, Dave; Dickey, Chad A

Selenica, Maj-Linda B; Davtyan, Hayk; Housley, Steven B; Blair, Laura J; Gillies, Anne; Nordhues, Bryce A; Zhang, Bo; Liu, Joseph; Gestwicki, Jason E; Lee, Daniel C; Gordon, Marcia N; Morgan, Dave; Dickey, Chad A.

Affiliation

Selenica ML; Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, 12901 Bruce B Downs Blvd, Tampa 33612, FL, USA. mselenic@health.usf.edu.

J Neuroinflammation ; 11: 152, 2014 Sep 03.

Article in En | MEDLINE | ID: mdl-25183004

Subject(s)

Epitope Mapping; Epitopes/immunology; Tauopathies/immunology; Tauopathies/therapy; Vaccination/methods; tau Proteins/immunology; Adjuvants, Immunologic/therapeutic use; Animals; Antibodies/blood; Cell Proliferation; Cytokines/metabolism; Disease Models, Animal; Encephalitis/etiology; Encephalitis/immunology; Encephalitis/therapy; Enzyme-Linked Immunosorbent Assay; Glial Fibrillary Acidic Protein/metabolism; Humans; Mice; Mice, Transgenic; Mutation/genetics; Quillaja Saponins; Saponins/therapeutic use; T-Lymphocytes/drug effects; Tauopathies/complications; Tauopathies/pathology; tau Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vaccination / Tau Proteins / Epitope Mapping / Tauopathies / Epitopes Type of study: Etiology_studies Limits: Animals / Humans Language: En Journal: J Neuroinflammation Journal subject: NEUROLOGIA Year: 2014 Type: Article Affiliation country: United States

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