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Identification of activators of ERK5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agents.
Le, Nhat-Tu; Takei, Yuichiro; Izawa-Ishizawa, Yuki; Heo, Kyung-Sun; Lee, Hakjoo; Smrcka, Alan V; Miller, Benjamin L; Ko, Kyung Ae; Ture, Sara; Morrell, Craig; Fujiwara, Keigi; Akaike, Masashi; Abe, Jun-ichi.
Affiliation
  • Le NT; Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
  • Takei Y; Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
  • Izawa-Ishizawa Y; Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
  • Heo KS; Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
  • Lee H; Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
  • Smrcka AV; Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
  • Miller BL; Department of Dermatology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642; and.
  • Ko KA; Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
  • Ture S; Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
  • Morrell C; Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
  • Fujiwara K; Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642;
  • Akaike M; Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, 770-8503, Japan jabe@mdanderson.org akaike.masashi@tokushima-u.ac.jp.
  • Abe J; Aab Cardiovascular Research Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642; jabe@mdanderson.org akaike.masashi@tokushima-u.ac.jp.
J Immunol ; 193(7): 3803-15, 2014 Oct 01.
Article in En | MEDLINE | ID: mdl-25187658
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Transcription, Genetic / Endothelium, Vascular / Heart Transplantation / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Mitogen-Activated Protein Kinase 7 / Graft Rejection / Antimalarials Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Animals / Humans Language: En Journal: J Immunol Year: 2014 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Transcription, Genetic / Endothelium, Vascular / Heart Transplantation / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Mitogen-Activated Protein Kinase 7 / Graft Rejection / Antimalarials Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Animals / Humans Language: En Journal: J Immunol Year: 2014 Type: Article