1,2,4-Benzothiadiazine-1,1-dioxide derivatives as ionotropic glutamate receptor ligands: synthesis and structure-activity relationships.

Varano, Flavia; Catarzi, Daniela; Colotta, Vittoria; Squarcialupi, Lucia; Matucci, Rosanna

Varano, Flavia; Catarzi, Daniela; Colotta, Vittoria; Squarcialupi, Lucia; Matucci, Rosanna.

Affiliation

Varano F; Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, Sezione di Farmaceutica e Nutraceutica, Università di Firenze, Sesto Fiorentino, Italy.

Arch Pharm (Weinheim) ; 347(11): 777-85, 2014 Nov.

Article in En | MEDLINE | ID: mdl-25204434

Subject(s)

Benzothiadiazines/chemical synthesis; Benzothiadiazines/metabolism; Excitatory Amino Acid Agents/chemical synthesis; Excitatory Amino Acid Agents/metabolism; Receptors, Ionotropic Glutamate/metabolism; Animals; Benzothiadiazines/pharmacology; Cerebral Cortex/metabolism; Excitatory Amino Acid Agents/pharmacology; Ligands; Molecular Structure; Protein Binding; Rats; Receptors, Ionotropic Glutamate/drug effects; Structure-Activity Relationship

Key words

1,2,4-Benzothiadiazine-1,1-dioxide; AMPA receptor; AMPA receptor antagonists; Ionotropic glutamate receptors; Neurological diseases

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzothiadiazines / Excitatory Amino Acid Agents / Receptors, Ionotropic Glutamate Limits: Animals Language: En Journal: Arch Pharm (Weinheim) Year: 2014 Type: Article Affiliation country: Italy

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