TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.

Alpern, Daniil; Langer, Diana; Ballester, Benoit; Le Gras, Stephanie; Romier, Christophe; Mengus, Gabrielle; Davidson, Irwin

Alpern, Daniil; Langer, Diana; Ballester, Benoit; Le Gras, Stephanie; Romier, Christophe; Mengus, Gabrielle; Davidson, Irwin.

Affiliation

Alpern D; Department of Functional Genomics and Cancer, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/UDS, Illkirch, France.
Langer D; Department of Functional Genomics and Cancer, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/UDS, Illkirch, France.
Ballester B; Laboratoire TAGC, Aix-Marseille Université, UMR1090, Marseille, France.
Le Gras S; Department of Functional Genomics and Cancer, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/UDS, Illkirch, France.
Romier C; Department of Integrated Structural Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/UDS, Illkirch, France.
Mengus G; Department of Functional Genomics and Cancer, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/UDS, Illkirch, France.
Davidson I; Department of Functional Genomics and Cancer, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/UDS, Illkirch, France.

Elife ; 3: e03613, 2014 Sep 10.

Article in En | MEDLINE | ID: mdl-25209997

Subject(s)

Cell Differentiation/genetics; Hepatocyte Nuclear Factor 4/metabolism; Hepatocytes/cytology; Hepatocytes/metabolism; Promoter Regions, Genetic; Protein Subunits/metabolism; Transcription Factor TFIID/metabolism; Animals; Animals, Newborn; Bile Ducts/metabolism; Bile Ducts/pathology; Cell Communication; Cholestasis/complications; Cholestasis/metabolism; Cholestasis/pathology; Down-Regulation/genetics; Genome; Hepatocyte Nuclear Factor 4/chemistry; Homeodomain Proteins/metabolism; Hypoglycemia/complications; Hypoglycemia/pathology; Mice; Mutation/genetics; Protein Binding/genetics; Protein Multimerization; Protein Structure, Tertiary; RNA Polymerase II/metabolism; TATA-Binding Protein Associated Factors; TATA-Box Binding Protein/metabolism; Transcription Factor TFIID/deficiency; Up-Regulation/genetics

Key words

biochemistry; bioinformatics; chromosomes; developmental biology; genes; genomics; mouse

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Differentiation / Promoter Regions, Genetic / Hepatocytes / Protein Subunits / Transcription Factor TFIID / Hepatocyte Nuclear Factor 4 Limits: Animals Language: En Journal: Elife Year: 2014 Type: Article Affiliation country: France

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