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Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing.
Carroll, Jean; Page, Tristan K W; Chiang, Shih-Chieh; Kalmar, Bernadett; Bode, David; Greensmith, Linda; Mckinnon, Peter J; Thorpe, Julian R; Hafezparast, Majid; El-Khamisy, Sherif F.
Affiliation
  • Carroll J; Genome Damage and Stability Center, University of Sussex, Brighton BN1 9RQ, UK.
  • Page TK; School of Life Science, University of Sussex, Brighton BN1 9QG, UK.
  • Chiang SC; Department of Molecular Biology and Biotechnology, Krebs Institute, University of Sheffield, Sheffield S10 2TN, UK.
  • Kalmar B; Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
  • Bode D; School of Life Science, University of Sussex, Brighton BN1 9QG, UK.
  • Greensmith L; Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
  • Mckinnon PJ; Department of Genetics, St Jude Children's Research Hospital, Memphis, TN 38105-3678, USA and.
  • Thorpe JR; School of Life Science, University of Sussex, Brighton BN1 9QG, UK.
  • Hafezparast M; School of Life Science, University of Sussex, Brighton BN1 9QG, UK s.el-khamisy@sheffield.ac.uk m.hafezparast@sussex.ac.uk.
  • El-Khamisy SF; Genome Damage and Stability Center, University of Sussex, Brighton BN1 9RQ, UK Department of Molecular Biology and Biotechnology, Krebs Institute, University of Sheffield, Sheffield S10 2TN, UK Center of Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza, Egy
Hum Mol Genet ; 24(3): 828-40, 2015 Feb 01.
Article in En | MEDLINE | ID: mdl-25274775
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Superoxide Dismutase / Transcription, Genetic / Nuclear Proteins / Aging, Premature / DNA-Binding Proteins / Motor Neurons Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2015 Type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Superoxide Dismutase / Transcription, Genetic / Nuclear Proteins / Aging, Premature / DNA-Binding Proteins / Motor Neurons Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2015 Type: Article Affiliation country: United kingdom