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Diversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors.
Lukens, Amanda K; Heidebrecht, Richard W; Mulrooney, Carol; Beaudoin, Jennifer A; Comer, Eamon; Duvall, Jeremy R; Fitzgerald, Mark E; Masi, Daniela; Galinsky, Kevin; Scherer, Christina A; Palmer, Michelle; Munoz, Benito; Foley, Michael; Schreiber, Stuart L; Wiegand, Roger C; Wirth, Dyann F.
Affiliation
  • Lukens AK; Infectious Disease Initiative, The Broad Institute, Cambridge Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston.
  • Heidebrecht RW; Infectious Disease Initiative, The Broad Institute, Cambridge.
  • Mulrooney C; Therapeutics Platform.
  • Beaudoin JA; Therapeutics Platform.
  • Comer E; Therapeutics Platform.
  • Duvall JR; Therapeutics Platform.
  • Fitzgerald ME; Therapeutics Platform.
  • Masi D; Therapeutics Platform.
  • Galinsky K; Genome Sequence and Analysis Program.
  • Scherer CA; Therapeutics Platform.
  • Palmer M; Therapeutics Platform.
  • Munoz B; Therapeutics Platform.
  • Foley M; Therapeutics Platform.
  • Schreiber SL; Center for the Science of Therapeutics, The Broad Institute, Cambridge, Massachusetts.
  • Wiegand RC; Infectious Disease Initiative, The Broad Institute, Cambridge.
  • Wirth DF; Infectious Disease Initiative, The Broad Institute, Cambridge Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston.
J Infect Dis ; 211(7): 1097-103, 2015 Apr 01.
Article in En | MEDLINE | ID: mdl-25336726
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Protozoan Proteins / Malaria, Falciparum / Cytochromes b / Drug Discovery / Antimalarials Limits: Humans Language: En Journal: J Infect Dis Year: 2015 Type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Protozoan Proteins / Malaria, Falciparum / Cytochromes b / Drug Discovery / Antimalarials Limits: Humans Language: En Journal: J Infect Dis Year: 2015 Type: Article