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Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.
Tan, Li; Wang, Jun; Tanizaki, Junko; Huang, Zhifeng; Aref, Amir R; Rusan, Maria; Zhu, Su-Jie; Zhang, Yiyun; Ercan, Dalia; Liao, Rachel G; Capelletti, Marzia; Zhou, Wenjun; Hur, Wooyoung; Kim, NamDoo; Sim, Taebo; Gaudet, Suzanne; Barbie, David A; Yeh, Jing-Ruey Joanna; Yun, Cai-Hong; Hammerman, Peter S; Mohammadi, Moosa; Jänne, Pasi A; Gray, Nathanael S.
Affiliation
  • Tan L; Departments of Biological Chemistry and Molecular Pharmacology, Departments of Cancer Biology and.
  • Wang J; Medical Oncology.
  • Tanizaki J; Medical Oncology, The Lowe Center for Thoracic Oncology.
  • Huang Z; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016; School of Pharmacy, Wenzhou Medical University, Wenzhou, 325035, China;
  • Aref AR; Medical Oncology, Genetics, and.
  • Rusan M; Medical Oncology, Department of Clinical Medicine, Aarhus University, Aarhus, 8200 Denmark;
  • Zhu SJ; Peking University Health Science Center, Beijing, 100191, China;
  • Zhang Y; Medicine, Harvard Medical School, Boston, MA 02115; Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129;
  • Ercan D; Medical Oncology, The Lowe Center for Thoracic Oncology.
  • Liao RG; Medical Oncology, Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA 02141;
  • Capelletti M; Medical Oncology, The Lowe Center for Thoracic Oncology.
  • Zhou W; Departments of Biological Chemistry and Molecular Pharmacology, Departments of Cancer Biology and.
  • Hur W; Departments of Biological Chemistry and Molecular Pharmacology, Departments of Cancer Biology and Chemical Kinomics Research Center, Korea Institute of Science and Technology, Seoul, 136-791 Republic of Korea;
  • Kim N; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 706-010 Republic of Korea; and.
  • Sim T; Chemical Kinomics Research Center, Korea Institute of Science and Technology, Seoul, 136-791 Republic of Korea; Korea University-Korean Institute of Science and Technology Graduate School of Converging Science and Technology, Seoul, 136-713 Republic of Korea.
  • Gaudet S; Departments of Cancer Biology and Genetics, and Center for Systems Cancer Biology, and.
  • Barbie DA; Medical Oncology.
  • Yeh JR; Medicine, Harvard Medical School, Boston, MA 02115; Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129;
  • Yun CH; Peking University Health Science Center, Beijing, 100191, China;
  • Hammerman PS; Medical Oncology, Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA 02141; Peter_Hammerman@dfci.harvard.edu Moosa.Mohammadi@nyumc.org pasi_janne@dfci.harvard.edu nathanael_gray@dfci.harvard.edu.
  • Mohammadi M; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016; Peter_Hammerman@dfci.harvard.edu Moosa.Mohammadi@nyumc.org pasi_janne@dfci.harvard.edu nathanael_gray@dfci.harvard.edu.
  • Jänne PA; Medical Oncology, The Lowe Center for Thoracic Oncology, Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, MA 02215; Peter_Hammerman@dfci.harvard.edu Moosa.Mohammadi@nyumc.org pasi_janne@dfci.harvard.edu nathanael_gray@dfci.harvard.edu.
  • Gray NS; Departments of Biological Chemistry and Molecular Pharmacology, Departments of Cancer Biology and Peter_Hammerman@dfci.harvard.edu Moosa.Mohammadi@nyumc.org pasi_janne@dfci.harvard.edu nathanael_gray@dfci.harvard.edu.
Proc Natl Acad Sci U S A ; 111(45): E4869-77, 2014 Nov 11.
Article in En | MEDLINE | ID: mdl-25349422
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Resistance, Neoplasm / Protein Kinase Inhibitors / Receptor, Fibroblast Growth Factor, Type 1 / Receptor, Fibroblast Growth Factor, Type 2 / Receptor, Fibroblast Growth Factor, Type 4 / Neoplasms / Antineoplastic Agents Language: En Journal: Proc Natl Acad Sci U S A Year: 2014 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Resistance, Neoplasm / Protein Kinase Inhibitors / Receptor, Fibroblast Growth Factor, Type 1 / Receptor, Fibroblast Growth Factor, Type 2 / Receptor, Fibroblast Growth Factor, Type 4 / Neoplasms / Antineoplastic Agents Language: En Journal: Proc Natl Acad Sci U S A Year: 2014 Type: Article