Mutants of human colon adenocarcinoma, selected for thymidylate synthase deficiency.

Houghton, P J; Germain, G S; Hazelton, B J; Pennington, J W; Houghton, J A

Houghton, P J; Germain, G S; Hazelton, B J; Pennington, J W; Houghton, J A.

Affiliation

Houghton PJ; Department of Biochemical and Clinical Pharmacology, Saint Jude Children's Research Hospital, Memphis, TN 38101.

Proc Natl Acad Sci U S A ; 86(4): 1377-81, 1989 Feb.

Article in En | MEDLINE | ID: mdl-2537495

Subject(s)

Adenocarcinoma/genetics; Colonic Neoplasms/genetics; Mutation; Thymidylate Synthase/deficiency; Tumor Cells, Cultured/enzymology; Adenocarcinoma/enzymology; Adenocarcinoma/pathology; Animals; Cell Division; Cell Line; Cell Survival; Clone Cells; Colonic Neoplasms/enzymology; Colonic Neoplasms/pathology; DNA Replication; Deoxyuridine/metabolism; Humans; Kinetics; Mice; Neoplasm Transplantation; Nucleoside-Phosphate Kinase/metabolism; Thymidine/metabolism; Transplantation, Heterologous; Tumor Cells, Cultured/cytology

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thymidylate Synthase / Tumor Cells, Cultured / Adenocarcinoma / Colonic Neoplasms / Mutation Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 1989 Type: Article

Fulltext

XML

PubMed Links

Search on Google