In vitro activity of clinically implemented ß-lactams against Aerococcus urinae: presence of non-susceptible isolates in Switzerland.
New Microbiol
; 37(4): 563-6, 2014 Oct.
Article
in En
| MEDLINE
| ID: mdl-25387295
ABSTRACT
We analyzed the in vitro susceptibility to several ?-lactams and vancomycin of 80 Aerococcus urinae isolates collected during 2011-2012 in Switzerland. MICs were determined by Etest (bioMérieux) on Müller-Hinton agar with 5% sheep blood and interpreted according to the CLSI and EUCAST criteria set for viridans streptococci. MIC50/90 for penicillin, amoxicillin, ceftriaxone and vancomycin were 0.016/0.064 mg/l, 0.032/0.064 mg/l, 0.125/0.5 mg/l and 0.38/0.5 mg/l, respectively. Three (3.8%) isolates were resistant to ceftriaxone regardless of the criteria used (MICs ?2 mg/l); one of them was also non-susceptible to penicillin (MIC of 0.25 mg/l) according to CLSI. ß-lactam resistance in A. urinae is a concern and suggests that more studies are needed to determine the molecular mechanisms of such resistance.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gram-Positive Bacterial Infections
/
Beta-Lactams
/
Aerococcus
/
Anti-Bacterial Agents
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
En
Journal:
New Microbiol
Journal subject:
MICROBIOLOGIA
Year:
2014
Type:
Article
Affiliation country:
Switzerland