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A cryo-electron microscopy study identifies the complete H16.V5 epitope and reveals global conformational changes initiated by binding of the neutralizing antibody fragment.
Lee, Hyunwook; Brendle, Sarah A; Bywaters, Stephanie M; Guan, Jian; Ashley, Robert E; Yoder, Joshua D; Makhov, Alexander M; Conway, James F; Christensen, Neil D; Hafenstein, Susan.
Affiliation
  • Lee H; Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
  • Brendle SA; Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
  • Bywaters SM; Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
  • Guan J; Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
  • Ashley RE; Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
  • Yoder JD; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Makhov AM; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Conway JF; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Christensen ND; Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
  • Hafenstein S; Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA shafenstein@hmc.psu.edu.
J Virol ; 89(2): 1428-38, 2015 Jan 15.
Article in En | MEDLINE | ID: mdl-25392224
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Capsid / Human papillomavirus 16 / Antibodies, Neutralizing / Antibodies, Viral / Epitopes / Antigens, Viral Language: En Journal: J Virol Year: 2015 Type: Article Affiliation country: United States
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Capsid / Human papillomavirus 16 / Antibodies, Neutralizing / Antibodies, Viral / Epitopes / Antigens, Viral Language: En Journal: J Virol Year: 2015 Type: Article Affiliation country: United States