Quantitative analysis of tissue distribution of the B16BL6-derived exosomes using a streptavidin-lactadherin fusion protein and iodine-125-labeled biotin derivative after intravenous injection in mice.

Morishita, Masaki; Takahashi, Yuki; Nishikawa, Makiya; Sano, Kohei; Kato, Kana; Yamashita, Takuma; Imai, Takafumi; Saji, Hideo; Takakura, Yoshinobu

Morishita, Masaki; Takahashi, Yuki; Nishikawa, Makiya; Sano, Kohei; Kato, Kana; Yamashita, Takuma; Imai, Takafumi; Saji, Hideo; Takakura, Yoshinobu.

Affiliation

Morishita M; Department of Biopharmaceutics and Drug Metabolism, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, 606-8501, Japan.

J Pharm Sci ; 104(2): 705-13, 2015 Feb.

Article in En | MEDLINE | ID: mdl-25393546

Subject(s)

Biotin/metabolism; Exosomes/metabolism; Iodine Radioisotopes/metabolism; Recombinant Fusion Proteins/metabolism; Streptavidin/metabolism; Animals; Biotin/administration & dosage; Biotin/analysis; Injections, Intravenous; Iodine Radioisotopes/administration & dosage; Iodine Radioisotopes/analysis; Male; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Protein Binding; Recombinant Fusion Proteins/administration & dosage; Recombinant Fusion Proteins/analysis; Streptavidin/analysis; Tissue Distribution/drug effects; Tissue Distribution/physiology

Key words

biomaterials; clearance; exosome; lactadherin; nanoparticles; pharmacokinetics; phospholipids; quantitative analysis; radioisotope; streptavidin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biotin / Recombinant Fusion Proteins / Streptavidin / Exosomes / Iodine Radioisotopes Limits: Animals Language: En Journal: J Pharm Sci Year: 2015 Type: Article Affiliation country: Japan

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