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Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase.
Zabka, Tanja S; Singh, Jatinder; Dhawan, Preeti; Liederer, Bianca M; Oeh, Jason; Kauss, Mara A; Xiao, Yang; Zak, Mark; Lin, Tori; McCray, Bobbi; La, Nghi; Nguyen, Trung; Beyer, Joseph; Farman, Cynthia; Uppal, Hirdesh; Dragovich, Peter S; O'Brien, Thomas; Sampath, Deepak; Misner, Dinah L.
Affiliation
  • Zabka TS; *Safety Assessment, Genentech, South San Francisco, California 94080, DMPK, Genentech, South San Francisco, California 94080, In-Vivo Pharmacology, Genentech, South San Francisco, California 94080, Translational Oncology, Genentech, South San Francisco, California 94080, Discovery Chemistry, Genente
  • Singh J; *Safety Assessment, Genentech, South San Francisco, California 94080, DMPK, Genentech, South San Francisco, California 94080, In-Vivo Pharmacology, Genentech, South San Francisco, California 94080, Translational Oncology, Genentech, South San Francisco, California 94080, Discovery Chemistry, Genente
  • Dhawan P; *Safety Assessment, Genentech, South San Francisco, California 94080, DMPK, Genentech, South San Francisco, California 94080, In-Vivo Pharmacology, Genentech, South San Francisco, California 94080, Translational Oncology, Genentech, South San Francisco, California 94080, Discovery Chemistry, Genente
  • Liederer BM; *Safety Assessment, Genentech, South San Francisco, California 94080, DMPK, Genentech, South San Francisco, California 94080, In-Vivo Pharmacology, Genentech, South San Francisco, California 94080, Translational Oncology, Genentech, South San Francisco, California 94080, Discovery Chemistry, Genente
  • Oeh J; *Safety Assessment, Genentech, South San Francisco, California 94080, DMPK, Genentech, South San Francisco, California 94080, In-Vivo Pharmacology, Genentech, South San Francisco, California 94080, Translational Oncology, Genentech, South San Francisco, California 94080, Discovery Chemistry, Genente
  • Kauss MA; *Safety Assessment, Genentech, South San Francisco, California 94080, DMPK, Genentech, South San Francisco, California 94080, In-Vivo Pharmacology, Genentech, South San Francisco, California 94080, Translational Oncology, Genentech, South San Francisco, California 94080, Discovery Chemistry, Genente
  • Xiao Y; *Safety Assessment, Genentech, South San Francisco, California 94080, DMPK, Genentech, South San Francisco, California 94080, In-Vivo Pharmacology, Genentech, South San Francisco, California 94080, Translational Oncology, Genentech, South San Francisco, California 94080, Discovery Chemistry, Genente
  • Zak M; *Safety Assessment, Genentech, South San Francisco, California 94080, DMPK, Genentech, South San Francisco, California 94080, In-Vivo Pharmacology, Genentech, South San Francisco, California 94080, Translational Oncology, Genentech, South San Francisco, California 94080, Discovery Chemistry, Genente
  • Lin T; *Safety Assessment, Genentech, South San Francisco, California 94080, DMPK, Genentech, South San Francisco, California 94080, In-Vivo Pharmacology, Genentech, South San Francisco, California 94080, Translational Oncology, Genentech, South San Francisco, California 94080, Discovery Chemistry, Genente
  • McCray B; *Safety Assessment, Genentech, South San Francisco, California 94080, DMPK, Genentech, South San Francisco, California 94080, In-Vivo Pharmacology, Genentech, South San Francisco, California 94080, Translational Oncology, Genentech, South San Francisco, California 94080, Discovery Chemistry, Genente
  • La N; *Safety Assessment, Genentech, South San Francisco, California 94080, DMPK, Genentech, South San Francisco, California 94080, In-Vivo Pharmacology, Genentech, South San Francisco, California 94080, Translational Oncology, Genentech, South San Francisco, California 94080, Discovery Chemistry, Genente
  • Nguyen T; *Safety Assessment, Genentech, South San Francisco, California 94080, DMPK, Genentech, South San Francisco, California 94080, In-Vivo Pharmacology, Genentech, South San Francisco, California 94080, Translational Oncology, Genentech, South San Francisco, California 94080, Discovery Chemistry, Genente
  • Beyer J; *Safety Assessment, Genentech, South San Francisco, California 94080, DMPK, Genentech, South San Francisco, California 94080, In-Vivo Pharmacology, Genentech, South San Francisco, California 94080, Translational Oncology, Genentech, South San Francisco, California 94080, Discovery Chemistry, Genente
  • Farman C; *Safety Assessment, Genentech, South San Francisco, California 94080, DMPK, Genentech, South San Francisco, California 94080, In-Vivo Pharmacology, Genentech, South San Francisco, California 94080, Translational Oncology, Genentech, South San Francisco, California 94080, Discovery Chemistry, Genente
  • Uppal H; *Safety Assessment, Genentech, South San Francisco, California 94080, DMPK, Genentech, South San Francisco, California 94080, In-Vivo Pharmacology, Genentech, South San Francisco, California 94080, Translational Oncology, Genentech, South San Francisco, California 94080, Discovery Chemistry, Genente
  • Dragovich PS; *Safety Assessment, Genentech, South San Francisco, California 94080, DMPK, Genentech, South San Francisco, California 94080, In-Vivo Pharmacology, Genentech, South San Francisco, California 94080, Translational Oncology, Genentech, South San Francisco, California 94080, Discovery Chemistry, Genente
  • O'Brien T; *Safety Assessment, Genentech, South San Francisco, California 94080, DMPK, Genentech, South San Francisco, California 94080, In-Vivo Pharmacology, Genentech, South San Francisco, California 94080, Translational Oncology, Genentech, South San Francisco, California 94080, Discovery Chemistry, Genente
  • Sampath D; *Safety Assessment, Genentech, South San Francisco, California 94080, DMPK, Genentech, South San Francisco, California 94080, In-Vivo Pharmacology, Genentech, South San Francisco, California 94080, Translational Oncology, Genentech, South San Francisco, California 94080, Discovery Chemistry, Genente
  • Misner DL; *Safety Assessment, Genentech, South San Francisco, California 94080, DMPK, Genentech, South San Francisco, California 94080, In-Vivo Pharmacology, Genentech, South San Francisco, California 94080, Translational Oncology, Genentech, South San Francisco, California 94080, Discovery Chemistry, Genente
Toxicol Sci ; 144(1): 163-72, 2015 Mar.
Article in En | MEDLINE | ID: mdl-25505128
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytokines / Enzyme Inhibitors / Nicotinamide Phosphoribosyltransferase / Retinal Pigment Epithelium Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans / Male Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2015 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytokines / Enzyme Inhibitors / Nicotinamide Phosphoribosyltransferase / Retinal Pigment Epithelium Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans / Male Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2015 Type: Article