The E3 ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin resistance.

Yang, Shuo; Wang, Bingwei; Humphries, Fiachra; Hogan, Andrew E; O'Shea, Donal; Moynagh, Paul N

Yang, Shuo; Wang, Bingwei; Humphries, Fiachra; Hogan, Andrew E; O'Shea, Donal; Moynagh, Paul N.

Affiliation

Yang S; Institute of Immunology, Department of Biology, National University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland.
Wang B; Institute of Immunology, Department of Biology, National University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland.
Humphries F; Institute of Immunology, Department of Biology, National University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland.
Hogan AE; Education and Research Centre, St Vincent's University Hospital, University College Dublin, Dublin 4, Ireland.
O'Shea D; Education and Research Centre, St Vincent's University Hospital, University College Dublin, Dublin 4, Ireland.
Moynagh PN; Institute of Immunology, Department of Biology, National University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland; Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast BT9 7AE, Northern Ireland, UK. Electronic address: pa

Immunity ; 41(6): 973-87, 2014 Dec 18.

Article in En | MEDLINE | ID: mdl-25526310

Subject(s)

Inflammation/immunology; Macrophages/physiology; Obesity/immunology; Ubiquitin-Protein Ligases/metabolism; Abdominal Fat/metabolism; Abdominal Fat/pathology; Adult; Aged; Animals; Cell Differentiation/genetics; Cells, Cultured; Diet, High-Fat; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Inflammation/etiology; Insulin Resistance/genetics; Interleukin-1beta/metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Obesity/complications; TNF Receptor-Associated Factor 6/metabolism; Ubiquitin-Protein Ligases/genetics; Ubiquitination/genetics; Young Adult

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ubiquitin-Protein Ligases / Inflammation / Macrophages / Obesity Type of study: Etiology_studies / Prognostic_studies Limits: Adult / Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2014 Type: Article Affiliation country: Ireland

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