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Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).
Leverson, J D; Zhang, H; Chen, J; Tahir, S K; Phillips, D C; Xue, J; Nimmer, P; Jin, S; Smith, M; Xiao, Y; Kovar, P; Tanaka, A; Bruncko, M; Sheppard, G S; Wang, L; Gierke, S; Kategaya, L; Anderson, D J; Wong, C; Eastham-Anderson, J; Ludlam, M J C; Sampath, D; Fairbrother, W J; Wertz, I; Rosenberg, S H; Tse, C; Elmore, S W; Souers, A J.
Affiliation
  • Leverson JD; Oncology Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Zhang H; Oncology Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Chen J; Oncology Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Tahir SK; Oncology Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Phillips DC; Oncology Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Xue J; Oncology Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Nimmer P; Oncology Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Jin S; Oncology Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Smith M; Oncology Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Xiao Y; Oncology Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Kovar P; Oncology Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Tanaka A; Oncology Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Bruncko M; Oncology Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Sheppard GS; Oncology Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Wang L; Oncology Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Gierke S; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Kategaya L; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Anderson DJ; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Wong C; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Eastham-Anderson J; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Ludlam MJ; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Sampath D; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Fairbrother WJ; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Wertz I; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Rosenberg SH; Oncology Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Tse C; Oncology Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Elmore SW; Oncology Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
  • Souers AJ; Oncology Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, IL 60064, USA.
Cell Death Dis ; 6: e1590, 2015 Jan 15.
Article in En | MEDLINE | ID: mdl-25590800
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Apoptosis / Small Molecule Libraries / Myeloid Cell Leukemia Sequence 1 Protein / Aniline Compounds / Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cell Death Dis Year: 2015 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Apoptosis / Small Molecule Libraries / Myeloid Cell Leukemia Sequence 1 Protein / Aniline Compounds / Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cell Death Dis Year: 2015 Type: Article Affiliation country: United States