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It still hurts: altered endogenous opioid activity in the brain during social rejection and acceptance in major depressive disorder.
Hsu, D T; Sanford, B J; Meyers, K K; Love, T M; Hazlett, K E; Walker, S J; Mickey, B J; Koeppe, R A; Langenecker, S A; Zubieta, J-K.
Affiliation
  • Hsu DT; 1] Department of Psychiatry, Stony Brook University, Stony Brook, NY, USA [2] Department of Psychiatry, The Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
  • Sanford BJ; Department of Psychiatry, The Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
  • Meyers KK; Department of Psychology, Wayne State University, Detroit, MI, USA.
  • Love TM; Department of Psychiatry, The Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
  • Hazlett KE; Department of Psychology, Marquette University, Milwaukee, WI, USA.
  • Walker SJ; Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA.
  • Mickey BJ; Department of Psychiatry, The Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
  • Koeppe RA; Department of Radiology, University of Michigan, Ann Arbor, MI, USA.
  • Langenecker SA; Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
  • Zubieta JK; 1] Department of Psychiatry, The Molecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA [2] Department of Radiology, University of Michigan, Ann Arbor, MI, USA.
Mol Psychiatry ; 20(2): 193-200, 2015 Feb.
Article in En | MEDLINE | ID: mdl-25600108
ABSTRACT
The µ-opioid receptor (MOR) system, well known for dampening physical pain, is also hypothesized to dampen 'social pain.' We used positron emission tomography scanning with the selective MOR radioligand [(11)C]carfentanil to test the hypothesis that MOR system activation (reflecting endogenous opioid release) in response to social rejection and acceptance is altered in medication-free patients diagnosed with current major depressive disorder (MDD, n=17) compared with healthy controls (HCs, n=18). During rejection, MDD patients showed reduced endogenous opioid release in brain regions regulating stress, mood and motivation, and slower emotional recovery compared with HCs. During acceptance, only HCs showed increased social motivation, which was positively correlated with endogenous opioid release in the nucleus accumbens, a reward structure. Altered endogenous opioid activity in MDD may hinder emotional recovery from negative social interactions and decrease pleasure derived from positive interactions. Both effects may reinforce depression, trigger relapse and contribute to poor treatment outcomes.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Psychological Distance / Social Facilitation / Brain / Receptors, Opioid, mu / Depressive Disorder, Major Type of study: Diagnostic_studies Limits: Adult / Female / Humans / Male Language: En Journal: Mol Psychiatry Journal subject: BIOLOGIA MOLECULAR / PSIQUIATRIA Year: 2015 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Psychological Distance / Social Facilitation / Brain / Receptors, Opioid, mu / Depressive Disorder, Major Type of study: Diagnostic_studies Limits: Adult / Female / Humans / Male Language: En Journal: Mol Psychiatry Journal subject: BIOLOGIA MOLECULAR / PSIQUIATRIA Year: 2015 Type: Article Affiliation country: United States