Antitumour efficacy of the selumetinib and trametinib MEK inhibitors in a combined human airway-tumour-stroma lung cancer model.

Mas, Christophe; Boda, Bernadett; CaulFuty, Mireille; Huang, Song; Wiszniewski, Ludovic; Constant, Samuel

Mas, Christophe; Boda, Bernadett; CaulFuty, Mireille; Huang, Song; Wiszniewski, Ludovic; Constant, Samuel.

Affiliation

Mas C; OncoTheis Sàrl, 14 chemin des aulx, CH-1228 Plan-les-Ouates, Geneva, Switzerland. Electronic address: christophe.mas@oncotheis.com.
Boda B; OncoTheis Sàrl, 14 chemin des aulx, CH-1228 Plan-les-Ouates, Geneva, Switzerland.
CaulFuty M; Epithelix Sàrl, Plan-les-Ouates, Switzerland.
Huang S; Epithelix Sàrl, Plan-les-Ouates, Switzerland.
Wiszniewski L; Epithelix Sàrl, Plan-les-Ouates, Switzerland.
Constant S; OncoTheis Sàrl, 14 chemin des aulx, CH-1228 Plan-les-Ouates, Geneva, Switzerland; Epithelix Sàrl, Plan-les-Ouates, Switzerland.

J Biotechnol ; 205: 111-9, 2015 Jul 10.

Article in En | MEDLINE | ID: mdl-25615947

Subject(s)

Benzimidazoles/pharmacology; Drug Screening Assays, Antitumor/methods; Lung Neoplasms/pathology; Protein Kinase Inhibitors/pharmacology; Pyridones/pharmacology; Pyrimidinones/pharmacology; Cell Proliferation/drug effects; Cells, Cultured; Epithelial Cells/cytology; Fibroblasts/cytology; Humans; Lung/cytology; Lung/pathology; Lung Neoplasms/drug therapy; Models, Biological; Tumor Microenvironment/drug effects

Key words

3D model; In vitro; Lung cancer; Preclinical; Tumour microenvironment

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridones / Pyrimidinones / Benzimidazoles / Drug Screening Assays, Antitumor / Protein Kinase Inhibitors / Lung Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biotechnol Journal subject: BIOTECNOLOGIA Year: 2015 Type: Article

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