Aliskiren restores renal AQP2 expression during unilateral ureteral obstruction by inhibiting the inflammasome.

Wang, Weidong; Luo, Renfei; Lin, Yu; Wang, Feifei; Zheng, Peili; Levi, Moshe; Yang, Tianxin; Li, Chunling

Wang, Weidong; Luo, Renfei; Lin, Yu; Wang, Feifei; Zheng, Peili; Levi, Moshe; Yang, Tianxin; Li, Chunling.

Affiliation

Wang W; Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China;
Luo R; Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China;
Lin Y; Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China;
Wang F; Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China;
Zheng P; Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China;
Levi M; Division of Renal Diseases and Hypertension, Anschutz Medical Campus, University of Colorado, Aurora, Colorado; and.
Yang T; Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China; Department of Medicine, University of Utah, and Veterans Affairs Medical Center, Salt Lake City, Utah.
Li C; Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China; lichl3@mail.sysu.edu.cn.

Am J Physiol Renal Physiol ; 308(8): F910-22, 2015 Apr 15.

Article in En | MEDLINE | ID: mdl-25694485

Subject(s)

Amides/pharmacology; Aquaporin 2/drug effects; Fumarates/pharmacology; Inflammasomes/antagonists & inhibitors; Kidney Diseases/prevention & control; Kidney/drug effects; Ureteral Obstruction/drug therapy; Angiotensin II Type 1 Receptor Blockers/pharmacology; Angiotensin-Converting Enzyme Inhibitors/pharmacology; Animals; Aquaporin 2/genetics; Aquaporin 2/metabolism; Carrier Proteins/metabolism; Cells, Cultured; Cytoprotection; Disease Models, Animal; Inflammasomes/metabolism; Inflammation Mediators/metabolism; Kidney/metabolism; Kidney Diseases/etiology; Kidney Diseases/genetics; Kidney Diseases/metabolism; Male; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; RNA, Messenger/metabolism; Rats, Wistar; Receptors, Cytoplasmic and Nuclear/metabolism; Renin/antagonists & inhibitors; Renin/metabolism; Renin-Angiotensin System/drug effects; Time Factors; Up-Regulation; Ureteral Obstruction/complications; Ureteral Obstruction/genetics; Ureteral Obstruction/metabolism

Key words

aquaporin 2; obstructive nephropathy; renin inhibition; water channel

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ureteral Obstruction / Aquaporin 2 / Inflammasomes / Fumarates / Amides / Kidney / Kidney Diseases Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Renal Physiol Journal subject: FISIOLOGIA / NEFROLOGIA Year: 2015 Type: Article

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