Interferon enhances the susceptibility of virus-infected fibroblasts to cytotoxic T cells.
J Exp Med
; 161(1): 257-62, 1985 Jan 01.
Article
in En
| MEDLINE
| ID: mdl-2578543
ABSTRACT
Interferon (IFN) pretreatment of low-passage mouse embryonic fibroblasts (MEF) infected with lymphocytic choriomeningitis virus or vaccinia virus rendered these cells two to three times more susceptible to lysis by H-2 restricted, virus-specific cytotoxic T lymphocytes (CTL) than control, virus-infected MEF. The increased sensitivity to lysis correlated with increased expression of surface H-2 antigens, but not viral antigens. Continuous cell lines already highly sensitive to CTL-mediated lysis and already expressing high levels of surface H-2 antigens were unaffected by IFN pretreatment. These results suggest that IFN treatment, by increasing surface H-2 levels, may result in increased association of surface H-2 and virus antigens, leading to enhanced recognition and lysis by virus-specific CTL.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vaccinia
/
T-Lymphocytes, Cytotoxic
/
Interferons
/
Fibroblasts
/
Lymphocytic Choriomeningitis
Limits:
Animals
Language:
En
Journal:
J Exp Med
Year:
1985
Type:
Article