Strained cyclooctyne as a molecular platform for construction of multimodal imaging probes.

Sun, Yao; Ma, Xiaowei; Cheng, Kai; Wu, Biying; Duan, Jianli; Chen, Hao; Bu, Lihong; Zhang, Ruiping; Hu, Xianming; Deng, Zixin; Xing, Lei; Hong, Xuechuan; Cheng, Zhen

Sun, Yao; Ma, Xiaowei; Cheng, Kai; Wu, Biying; Duan, Jianli; Chen, Hao; Bu, Lihong; Zhang, Ruiping; Hu, Xianming; Deng, Zixin; Xing, Lei; Hong, Xuechuan; Cheng, Zhen.

Affiliation

Sun Y; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and Wuhan University School of Pharmaceutical Sciences, Wuhan 430071 (China); Molecular Imaging Program at Stanford (MIPS), Bio-X Program, and Department of Radiology, Stanford University, California, 94305-5344 (USA).

Angew Chem Int Ed Engl ; 54(20): 5981-4, 2015 May 11.

Article in En | MEDLINE | ID: mdl-25800807

Subject(s)

Alkynes/chemistry; Cyclooctanes/chemistry; Molecular Imaging; Molecular Probes/chemistry; Neoplasms, Experimental/diagnosis; Alkynes/pharmacokinetics; Animals; Cell Line, Tumor; Cyclooctanes/pharmacokinetics; Disease Models, Animal; Humans; Mice; Molecular Probes/pharmacokinetics; Molecular Structure; Positron-Emission Tomography; Sulfhydryl Compounds/chemistry; Sulfhydryl Compounds/pharmacokinetics

Key words

alkynes; fluorescence; imaging agents; strained molecules; thiols

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Molecular Probes / Cyclooctanes / Alkynes / Molecular Imaging / Neoplasms, Experimental Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Angew Chem Int Ed Engl Year: 2015 Type: Article

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