Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2/SN-38 Antibody-Drug Conjugate: Characterization and Efficacy in Pancreatic, Gastric, and Other Cancers.

Cardillo, Thomas M; Govindan, Serengulam V; Sharkey, Robert M; Trisal, Preeti; Arrojo, Roberto; Liu, Donglin; Rossi, Edmund A; Chang, Chien-Hsing; Goldenberg, David M

Cardillo, Thomas M; Govindan, Serengulam V; Sharkey, Robert M; Trisal, Preeti; Arrojo, Roberto; Liu, Donglin; Rossi, Edmund A; Chang, Chien-Hsing; Goldenberg, David M.

Affiliation

Cardillo TM; Immunomedics, Inc., Morris Plains, New Jersey 07950, United States.
Govindan SV; Immunomedics, Inc., Morris Plains, New Jersey 07950, United States.
Sharkey RM; Immunomedics, Inc., Morris Plains, New Jersey 07950, United States.
Trisal P; Immunomedics, Inc., Morris Plains, New Jersey 07950, United States.
Arrojo R; Immunomedics, Inc., Morris Plains, New Jersey 07950, United States.
Liu D; Immunomedics, Inc., Morris Plains, New Jersey 07950, United States.
Rossi EA; Immunomedics, Inc., Morris Plains, New Jersey 07950, United States.
Chang CH; IBC Pharmaceuticals, Inc., Morris Plains, New Jersey 07950, United States.
Goldenberg DM; Immunomedics, Inc., Morris Plains, New Jersey 07950, United States.

Bioconjug Chem ; 26(5): 919-31, 2015 May 20.

Article in En | MEDLINE | ID: mdl-25915780

Subject(s)

Antibodies, Monoclonal, Humanized/pharmacology; Antibodies, Monoclonal/chemistry; Antigens, Neoplasm/immunology; Camptothecin/analogs & derivatives; Cell Adhesion Molecules/immunology; Immunoconjugates/pharmacology; Pancreatic Neoplasms/drug therapy; Stomach Neoplasms/drug therapy; Animals; Antibodies, Monoclonal/immunology; Antibodies, Monoclonal, Humanized/chemistry; Antibodies, Monoclonal, Humanized/pharmacokinetics; Antibodies, Monoclonal, Humanized/therapeutic use; Antibody-Dependent Cell Cytotoxicity/drug effects; Antigens, Neoplasm/metabolism; Apoptosis/drug effects; Camptothecin/chemistry; Camptothecin/pharmacokinetics; Camptothecin/pharmacology; Camptothecin/therapeutic use; Cell Adhesion Molecules/metabolism; Cell Line, Tumor; Clinical Trials as Topic; Female; Gene Expression Regulation, Neoplastic/drug effects; Humans; Immunoconjugates/chemistry; Immunoconjugates/pharmacokinetics; Immunoconjugates/therapeutic use; Irinotecan; Mice; Pancreatic Neoplasms/immunology; Pancreatic Neoplasms/metabolism; Pancreatic Neoplasms/pathology; Signal Transduction/drug effects; Stomach Neoplasms/immunology; Stomach Neoplasms/metabolism; Stomach Neoplasms/pathology; Xenograft Model Antitumor Assays

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Stomach Neoplasms / Camptothecin / Cell Adhesion Molecules / Immunoconjugates / Antibodies, Monoclonal, Humanized / Antibodies, Monoclonal / Antigens, Neoplasm Language: En Journal: Bioconjug Chem Journal subject: BIOQUIMICA Year: 2015 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google