Complete response and long-term survival (>20 years) of a child with tectal glioma: a case report.
Pediatr Neurosurg
; 50(2): 99-103, 2015.
Article
in En
| MEDLINE
| ID: mdl-25926271
ABSTRACT
Tectal glioma is a midbrain tumor. The patient generally presents with symptoms related to increased intracranial pressure and requires treatment for hydrocephalus. No effective pharmacological treatments have yet been introduced. This report discusses a case of a 13-year-old male diagnosed with tectal glioma who obtained a complete response and long-term survival after the treatment with antineoplastons (ANP) in phase II trial. Prior treatment consisted of placement of a ventriculoperitoneal shunt. After 6 years of stabilization there had been an increase in tumor size with signs of malignant transformation. The patient received treatment with ANP A10 and AS2-1 infusions for 20 months, obtained a complete response, and was switched to maintenance with ANP capsules. All treatments were discontinued in December 2003. Adverse events according to CTCAE v3.0 included hypernatremia (two events of grade 3, one event of grade 2, four events of grade 1), one case of fatigue (grade 2), and one allergic reaction (grade 1). Currently, over 20 years from his diagnosis and over 13 years from treatment start he is symptom-free and leads a normal life. This report indicates that it is possible to obtain long-term survival of a child with tectal glioma with currently available investigational treatment.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenylacetates
/
Piperidones
/
Brain Neoplasms
/
Benzeneacetamides
/
Glioma
/
Glutamine
/
Neoplasm Recurrence, Local
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Humans
/
Male
Language:
En
Journal:
Pediatr Neurosurg
Journal subject:
NEUROCIRURGIA
/
PEDIATRIA
Year:
2015
Type:
Article
Affiliation country:
United States