Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133(+) sphere-forming cells in liver stem cells.

Lin, Rui-Xin; Gong, Lu-Lu; Fan, Li-Mei; Zhao, Zhong-Kai; Yang, Shu-Li

Lin, Rui-Xin; Gong, Lu-Lu; Fan, Li-Mei; Zhao, Zhong-Kai; Yang, Shu-Li.

Affiliation

Lin RX; Department of Hepato-Biliary-Pancreatic Surgery, The Second Hospital of Jilin University Changchun 130041, China.
Gong LL; Department of Hepato-Biliary-Pancreatic Surgery, The Second Hospital of Jilin University Changchun 130041, China.
Fan LM; Department of Obstetrics and Gynecology, The Second Hospital of Jilin University Changchun 130041, China.
Zhao ZK; Department of Medicine, Jilin University Changchun 130041, China.
Yang SL; Department of Obstetrics and Gynecology, The Second Hospital of Jilin University Changchun 130041, China.

Int J Clin Exp Pathol ; 8(2): 1427-34, 2015.

Article in En | MEDLINE | ID: mdl-25973027

Subject(s)

Antineoplastic Agents/pharmacology; Carcinoma, Hepatocellular/pathology; Chalcone/pharmacology; Liver Neoplasms/pathology; Neoplastic Stem Cells/drug effects; Triterpenes/pharmacology; AC133 Antigen; Antigens, CD/metabolism; Cell Differentiation/drug effects; Cell Line, Tumor; Cell Separation; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glycoproteins/metabolism; Humans; Peptides/metabolism; Ursolic Acid

Key words

Self-renewal; cell differentiation; hepatocellular carcinoma; therapeutic agent

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Neoplastic Stem Cells / Chalcone / Carcinoma, Hepatocellular / Liver Neoplasms / Antineoplastic Agents Limits: Humans Language: En Journal: Int J Clin Exp Pathol Journal subject: PATOLOGIA Year: 2015 Type: Article Affiliation country: China

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