Interleukin-8 upregulates integrin ß3 expression and promotes estrogen receptor-negative breast cancer cell invasion by activating the PI3K/Akt/NF-&#954;B pathway.

Shao, Nan; Lu, Zhenhai; Zhang, Yunjian; Wang, Mian; Li, Wen; Hu, Ziye; Wang, Shenming; Lin, Ying

Interleukin-8 upregulates integrin ß3 expression and promotes estrogen receptor-negative breast cancer cell invasion by activating the PI3K/Akt/NF-κB pathway.

Shao, Nan; Lu, Zhenhai; Zhang, Yunjian; Wang, Mian; Li, Wen; Hu, Ziye; Wang, Shenming; Lin, Ying.

Affiliation

Shao N; Breast Disease Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Lu Z; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Zhang Y; Breast Disease Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Wang M; Breast Disease Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Li W; Laboratory of General Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Hu Z; Breast Disease Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Wang S; Breast Disease Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China. Electronic address: shenmingwang@hotmail.com.
Lin Y; Breast Disease Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China. Electronic address: frostlin@hotmail.com.

Cancer Lett ; 364(2): 165-72, 2015 Aug 10.

Article in En | MEDLINE | ID: mdl-25979232

Subject(s)

Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Integrin beta3/biosynthesis; Interleukin-8/metabolism; Receptors, Estrogen/metabolism; Breast Neoplasms/genetics; Cell Line, Tumor; Female; Humans; Interleukin-8/genetics; MCF-7 Cells; NF-kappa B/metabolism; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; RNA, Small Interfering/genetics; Signal Transduction; Transcriptional Activation; Up-Regulation

Key words

Breast cancer; IL-8; Integrin ß3; NF-κB; PI3K/Akt

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Receptors, Estrogen / Interleukin-8 / Integrin beta3 Limits: Female / Humans Language: En Journal: Cancer Lett Year: 2015 Type: Article Affiliation country: China

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