Ulinastatin decreases permeability of blood--brain barrier by inhibiting expression of MMP-9 and t-PA in postoperative aged rats.

Ma, Li; Zhang, Hui; Liu, Yong-zhe; Yin, Yan-ling; Ma, Ya-qun; Zhang, Sheng-suo

Ma, Li; Zhang, Hui; Liu, Yong-zhe; Yin, Yan-ling; Ma, Ya-qun; Zhang, Sheng-suo.

Affiliation

Ma L; a Department of Anesthesiology , General Hospital of Beijing Military Command , Beijing , China and.
Zhang H; b Department of Neurosurgery , Air Force General Hospital of the Chinese PLA , Beijing , China.
Liu YZ; a Department of Anesthesiology , General Hospital of Beijing Military Command , Beijing , China and.
Yin YL; a Department of Anesthesiology , General Hospital of Beijing Military Command , Beijing , China and.
Ma YQ; a Department of Anesthesiology , General Hospital of Beijing Military Command , Beijing , China and.
Zhang SS; a Department of Anesthesiology , General Hospital of Beijing Military Command , Beijing , China and.

Int J Neurosci ; 126(5): 463-8, 2016.

Article in En | MEDLINE | ID: mdl-26000820

Subject(s)

Blood-Brain Barrier/drug effects; Glycoproteins/pharmacology; Matrix Metalloproteinase 9/metabolism; Tissue Plasminogen Activator/metabolism; Trypsin Inhibitors/pharmacology; Animals; Blood-Brain Barrier/metabolism; Claudin-5/metabolism; Hepatectomy/adverse effects; Hippocampus/drug effects; Hippocampus/metabolism; Inflammation/etiology; Inflammation/metabolism; Male; NF-kappa B/metabolism; Permeability/drug effects; Rats; Rats, Sprague-Dawley; Zonula Occludens-1 Protein/metabolism

Key words

bloodbrain barrier; neuroinflammation; t-PA, MMP-9; ulinastatin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood-Brain Barrier / Glycoproteins / Trypsin Inhibitors / Tissue Plasminogen Activator / Matrix Metalloproteinase 9 Type of study: Etiology_studies Limits: Animals Language: En Journal: Int J Neurosci Year: 2016 Type: Article

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