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Evaluation of drug-induced QT interval prolongation in animal and human studies: a literature review of concordance.
Vargas, Hugo M; Bass, Alan S; Koerner, John; Matis-Mitchell, Sherri; Pugsley, Michael K; Skinner, Matthew; Burnham, Matthew; Bridgland-Taylor, Matthew; Pettit, Syril; Valentin, Jean-Pierre.
Affiliation
  • Vargas HM; Integrated Discovery and Safety Pharmacology, Amgen, Inc., Thousand Oaks, CA, USA.
  • Bass AS; Safety Assessment, Merck Research Laboratories, Boston, MA, USA.
  • Koerner J; Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA.
  • Matis-Mitchell S; Discovery Information, AstraZeneca R&D, Wilmington, DE, USA.
  • Pugsley MK; Safety and Exploratory Pharmacology, Janssen R&D, Raritan, NJ, USA.
  • Skinner M; Safety Assessment, AstraZeneca R&D, Cheshire, UK.
  • Burnham M; Safety Assessment, AstraZeneca R&D, Cheshire, UK.
  • Bridgland-Taylor M; Safety Assessment, AstraZeneca R&D, Cheshire, UK.
  • Pettit S; Health and Environmental Sciences Institute, Washington, DC, USA.
  • Valentin JP; Safety Assessment, AstraZeneca R&D, Cheshire, UK.
Br J Pharmacol ; 172(16): 4002-11, 2015 Aug.
Article in En | MEDLINE | ID: mdl-26031452
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Long QT Syndrome Type of study: Diagnostic_studies / Guideline / Prognostic_studies Limits: Animals / Humans Language: En Journal: Br J Pharmacol Year: 2015 Type: Article Affiliation country: United States
Fulltext
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Long QT Syndrome Type of study: Diagnostic_studies / Guideline / Prognostic_studies Limits: Animals / Humans Language: En Journal: Br J Pharmacol Year: 2015 Type: Article Affiliation country: United States