Angiogenesis Inducing Agents/pharmacology; Drugs, Chinese Herbal/pharmacology; Endothelial Cells/drug effects; Endothelium, Vascular/drug effects; Hypoxia/drug therapy; Animals; Cell Hypoxia; Cell Proliferation/drug effects; Cells, Cultured; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells/metabolism; Endothelium, Vascular/metabolism; Endothelium, Vascular/physiopathology; Gene Expression Regulation; Humans; Hypoxia/metabolism; Hypoxia/physiopathology; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors/genetics; Kruppel-Like Transcription Factors/metabolism; Male; Mice, Inbred C57BL; Neovascularization, Physiologic/drug effects; Phosphorylation; Tight Junction Proteins/genetics; Tight Junction Proteins/metabolism; Tight Junctions/drug effects; Tight Junctions/metabolism; Transfection