Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling.
Trends Biochem Sci
; 40(8): 435-45, 2015 Aug.
Article
in En
| MEDLINE
| ID: mdl-26067716
ABSTRACT
Peroxiredoxins (Prxs) are a ubiquitous family of cysteine-dependent peroxidase enzymes that play dominant roles in regulating peroxide levels within cells. These enzymes, often present at high levels and capable of rapidly clearing peroxides, display a remarkable array of variations in their oligomeric states and susceptibility to regulation by hyperoxidative inactivation and other post-translational modifications. Key conserved residues within the active site promote catalysis by stabilizing the transition state required for transferring the terminal oxygen of hydroperoxides to the active site (peroxidatic) cysteine residue. Extensive investigations continue to expand our understanding of the scope of their importance as well as the structures and forces at play within these critical defense and regulatory enzymes.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peroxides
/
Signal Transduction
/
Oxidative Stress
/
Peroxiredoxins
Limits:
Animals
/
Humans
Language:
En
Journal:
Trends Biochem Sci
Year:
2015
Type:
Article
Affiliation country:
United States