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Early life lead exposure causes gender-specific changes in the DNA methylation profile of DNA extracted from dried blood spots.
Sen, Arko; Heredia, Nicole; Senut, Marie-Claude; Hess, Matthew; Land, Susan; Qu, Wen; Hollacher, Kurt; Dereski, Mary O; Ruden, Douglas M.
Affiliation
  • Sen A; Institute of Environmental Health Sciences, Wayne State University, 2727 Second Avenue, Detroit, MI 48201, USA.
  • Heredia N; Department of Pharmacology, Wayne State University, Room 4000, 2727 Second Avenue, Detroit, MI 48201, USA.
  • Senut MC; Department of Obstetrics & Gynecology, Wayne State University, 3750 Woodward Avenue, Detroit, MI 48201, USA.
  • Hess M; Institute of Environmental Health Sciences, Wayne State University, 2727 Second Avenue, Detroit, MI 48201, USA.
  • Land S; Department of Obstetrics & Gynecology, Wayne State University, 3750 Woodward Avenue, Detroit, MI 48201, USA.
  • Qu W; CS Mott Center for Human Growth & Development, Wayne State University, 275 E Hancock St, Detroit, MI 48201, USA.
  • Hollacher K; Department of Obstetrics & Gynecology, Wayne State University, 3750 Woodward Avenue, Detroit, MI 48201, USA.
  • Dereski MO; Department of Pharmacology, Wayne State University, Room 4000, 2727 Second Avenue, Detroit, MI 48201, USA.
  • Ruden DM; Union College, 807 Union St, Schenectady, NY 12308, USA.
Epigenomics ; 7(3): 379-93, 2015.
Article in En | MEDLINE | ID: mdl-26077427
ABSTRACT

AIMS:

In this paper, we tested the hypothesis that early life lead (Pb) exposure associated DNA methylation (5 mC) changes are dependent on the sex of the child and can serve as biomarkers for Pb exposure.

METHODS:

In this pilot study, we measured the 5mC profiles of DNA extracted from dried blood spots (DBS) in a cohort of 43 children (25 males and 18 females; ages from 3 months to 5 years) from Detroit. Result &

Discussion:

We found that the effect of Pb-exposure on the 5-mC profiles can be separated into three subtypes affected methylation loci which are conserved irrespective of the sex of the child (conserved); affected methylation loci unique to males (male-specific); and affected methylation loci unique to females (female-specific).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Methylation / Lead Type of study: Etiology_studies Limits: Child, preschool / Female / Humans / Infant / Male Language: En Journal: Epigenomics Year: 2015 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Methylation / Lead Type of study: Etiology_studies Limits: Child, preschool / Female / Humans / Infant / Male Language: En Journal: Epigenomics Year: 2015 Type: Article Affiliation country: United States